Problem 1: Design (but do not implement) an experiment to test the three models of DNA replication. Summarize the results you would expect if each of the three models of DNA replication were correct. Assume you have access in a laboratory to the following: an experimental organism such as E. coli, an unlimited variety of isotopes, a test tube and centrifuge, and organic growth media.
Problem 2: Explain why half of DNA is replicated in a discontinuous fashion.
Problem 3: You isolate a DNA strand in which the joining together of Okazaki fragments is impaired and suspect that a mutation has occurred in an enzyme found at the replication fork. Which enzyme is most likely mutated?