Question: Double-stranded DNA molecules are described as anti-parallel. Which of the following is/are true regarding the structure of DNA and its replication? Question options: The two sugar-phosphate backbones run in opposite 5' --> 3' directions. Replication results in new complementary strands that are oriented in the opposite ( 5' --> 3') direction as their template strands. Both the leading and lagging strands add nucleotides in a 5' to 3' direction. (All of the above are true.) Need Assignment Help?