Which of the following statements is wrong regarding eukaryotic replication origins?
A. More origins are licensed and initiated within embryonic cells than in adult cells.
B. Replication is committed to initiate from an origin once it is bound by the pre-replication complex.
C. During a cell cycle only a subset of potential replication origins are licensed.
D. A eukaryotic replication origin is explained by various factors including DNA sequence, DNA topology and chromatin structure.