Which of the following best explains why an enzyme hasn't evolved to catalyze the following reaction as the first step of glycolysis?
glucose + inorganic phosphate glucose-6-phosphate
a. The use of ATP is required for this step to serve as a regulatory control point.
b. The use of ATP is important because it helps keep the concentration low. Otherwise the high [ATP] would slow glycolysis too much through feedback inhibition.
c. The large positive ?G°' of this reaction would need to be overcome by an exceedingly high [Pi].
d. What are you talking about? That's exactly what does happen.
e. None of the above provide a reasonable explanation.