A new drug for hyperlipidemia was compared with a current drug in a Randomized Control Drug of 10000 patients. After two years, the primary outcome, serum cholesterol, was 238 mg/dL in the group receiving the new drug and 240 mg/dL in the group receiving the old drug (p<0.001). Which of the following best describes the meaning of the p-value in the study?
Bias is unlikely to account for the observed difference.
The difference is clinically significant.
A difference as big or bigger than what was observed could have arisen by chance of one in 1000.
The results are generalizable to other patients with hypertension.
The statistical power of the study was inadequate.