Problem
Paget's disease of bone most commonly occurs in the pelvis, skull, spine, and legs. Risk factors include increasing age and a family history of the condition. Over time, affected bones may become fragile and misshapen.
When a person develops Paget's disease, for unknown reasons the collagen fibers in the bone matrix run randomly in all directions. In addition, there is a reduction in the amount of trabecular bone.
What symptoms would you expect to observe and why?