Problem: Several histidine residues in hemoglobin are involved in sensing pH by binding the protons. One important member is His46 on the b-chain of hemoglobin, whose side chain is in close proximity to the side chain of Asp94 in the deoxy from of hemoglobin but not the oxy-form. Use what you learned in class, hypothesize what kind of interaction may occur between Asp94 and His146 in deoxyhemoglobin