Discussion:
Genetics/DNA Problems
You are studying a human disease that is inherited in an autosomal dominant
fashion. You recognize that the disease maps to chromosome 10, so you obtain four DNA probes that hybridize to different chromosome 10 regions. A family in which the disease appears presents itself to a medical genetics clinic. DNA is extracted from each family member shown, cut with a restriction enzyme and tested on a Southern blot with each probe.
1. Which probe would be most useful for your studies and for genetic counseling? Explain.
2. Does the DNA probe that you selected in part a) actually include the disease gene? Explain.
3. What is unusual about individual ? What is the most likely explanation? Hint: Think outside the box.
Attachment:- Problems.rar