Problem 1: The risk of developing a complex genetic disease for European individuals homozygous for genotype A/A is RR=3.4 and the yearly incidence among Europeans is 1/10000. What is the expected yearly incidence among individuals with genotype A/A?
Problem 2: For particular DNA site in a sample of 2 chromosomes from a randomly mating diploid population of N=10,000 individuals that conforms to the assumptions of the coalescent theory what is the probability that no coalescence has occurred by generation 1000?