A. What is the orientation of the hydroxyl group when the compound is in chloroform solution? What evidence supports this?
B. What is the significance of the very small coupling observed between one of the C4 hydrogens and one of the C2 hydrogens?
C. In water and DMSO there is evidently a conformational change.What evidence is there for this, and why does such a change occur?
D. Calculations suggested that the lowest energy conformation in the gas phase or in non-polar solutions had one N-H group equatorial and one axial. Why would this be preferred over alternatives having either both N-H groups axial or both equatorial?