Problem 1: Why is it relatively difficult to identify stem cells in the adult pulmonary system, compared to skin or intestinal systems? What strategies have been applied to study these stem cells? Please comparatively assay the advantages and disadvantages about these strategies
Problem 2: There are four stages in human lung development prior to birth with different types of airway stem or progenitor cells driving each stage of development. Please list at least three types of stem cells and briefly discuss their roles in lung generation.
Problem 3: A veteran is hospitalized after enduring a painful brain injury. Magnetic resonance image (MRI) shows substantial injury in the cerebellum area. Which function of the body is affected due to the cerebellum damage? Explain the anatomical structure and function of Cerebellum and Pons. An important biological barrier protects the brain. What is the name of that barrier and what are the cells majorly involved in it? Explain the function of those cells.
Problem 4: What is the location of neural stem cells (NSC) in embryo and adult? What are the steps involved in the differentiation of embryonic stem cells into neuron, and glia cells? What are the ways for derivation of neural stem cell (NSC)? Give one example for each method.