Question 1. A survey of a SNP (Single Nucleotide Polymorphism) site segregating for nucleotides C and G in a chimpanzee population found the following numbers of the different genotypes:
What is the frequency of G and what are the expected numbers of the three genotypes?
Question 2. Assume that the frequencies for A2 for an autosomal locus in males and females are 0.8 and 0.4, respectively. Calculate the genotype frequencies for the next two generations. Derive the last two equations in expression 2.6b. (pages 76-78)
Question 3. A survey of cat owners revealed the following distribution of coat colors: 326 wildtype, 161 tortoise shell, and 13 orange. What is the frequency of the dominant orange allele in these female cats? What are the expected frequencies of the three genotypes? Discuss the difference between the observed and expected genotype frequencies. In male cats, 168 wildtype and 32 orange cats were observed. What is the frequency of the orange allele in these male cats?
Question 4. The number of newborn Americans of European ancestry who have the recessive autosomal disease cystic fibrosis is approximately 1 in 2500.
What is the estimated frequency of the disease allele?
q2 =1/2500, so q=0.02
In random mating population, what proportion of mating would be between two carriers?
4p2 q2 =0.0013
What proportion of individuals would be heterozygotes for this allele?
2pq=0.0358