Problem:
Primary generalized osteoarthritis (PGO) is caused by an autosomal gene that acts as a dominant in females and a recessive in males. If an unaffected man (whose father had the disease) marries an affected woman (who had an affected father and a normal mother),
Required:
Question: what is the probability that
(i) their son will be affected and
(ii) their daughter will be affected?
Show the pedigree and your calculation.