Problem:
Two types of signals have been implicated in metaphase checkpoint arrest. Consider the results of a recent experiment in which the unattached kinetochore of a monoattached chromosome was destroyed by a laser beam. It was found in this study that, following destruction of the kinetochore, the cell entered anaphase even though this chromosome was not properly aligned at the metaphase plate.
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Question: How might you interpret this experiment in terms of the checkpoint signals?
Provide a brief explanation for your answer.