What is first-line therapy for osteoarthritis and mechanism


Discussion Post: Osteoarthritis, Celebrex, & Ibuprofen

Sally is a 50-year-old female who has been a jogger for several years. She has recently been diagnosed with osteoarthritis. She has been taking ibuprofen for 3 months but states that "it does not help" and hurts her stomach. The health care provider prescribes celecoxib (Celebrex) 100 mg orally twice a day.

• What is the first-line therapy for osteoarthritis and the mechanism of action?

• Sally expresses concern about all the recent news about heart problems and celecoxib (Celebrex). What information should be included in a teaching plan to help her understand about taking celecoxib and the benefits and risks?

• Ibuprofen and celecoxib are both nonsteroidal anti-inflammatory drugs. Explain how they are similar and different.

The response should include a reference list. Double-space, using Times New Roman 12 pnt font, one-inch margins, and APA style of writing and citations.

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