What is drugs dose-limiting toxicity


Problem

1) Compare 2 cytotoxic anti-cancer treatments from different classes that act on different phases of the cell cycle, excluding the S phase. State their drug category and compare the mechanism of action

2) For the same two drugs, what is their dose-limiting toxicity? Determine whether it's via the PD or PK that this side effect occurs. Compare the mechanisms for this. Then compare the mechanism of action for resistance against this drug

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