Problem: Nurse Liam is assessing a patient with fatigue, weight gain, and cold intolerance, and suspects Hashimoto's thyrolditis. What is the primary pathophysiological mechanism of Hashimoto's thyroiditis, and which diagnostic test is most indicative of this condition? Need Assignment Help? A. O Increased production of TSH; Serum TSH levels B. O Autoimmune destruction of thyroid tissue; Anti-thyroid peroxidase (anti-TPO) antibodies C. O Overproduction of cortisol; Serum cortisol levels D. O Excessive production of thyroid hormones; Serum 13 and T4 levels