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What experiment would you do first to determine which

You are investigating a compound that causes neurotoxicity but the mechanism is unknown, and you are trying to determing the target of the compound. You have evidence that the compound acts through a receptor - what experiment would you do first to determine which receptors the drug interacts with? Why?

Once you have determined that the compound binds to a specific receptor, what would you do experimentally to determine if the drug is an agonist or antagonist?

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