What determines the toxicity of a chemical to what extent, Science

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What determines the toxicity of a chemical to what extent

Identify and describe five factors that affect responses to a toxic chemical.

What determines the toxicity of a chemical? To what extent do you agree with the assumption that "all substances are poisons"?
What is human exposure assessment? Explain some of the methods of exposure assessment.
Why is epidemiology important to research studies of environmental health? Give reasoning to support your answer.
What are some of the important limitations of the epidemiologic approach with respect to the study of environmental health problems?

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