Problem
Leigh's disease is a rare inherited neuro-metabolic disorder that affects the central nervous system. his progressive disorder begins in infants between the ages of three months and two years. Rarely, it occurs in teenagers and adults. The condition leads to the inability to effectively produce ATP due toa defective gene for one of the ATPase enzymes. Leigh's disease can be caused by deficiencies of an enzyme called pyruvate dehydrogenase. Symptoms of Leigh's disease usually progress rapidly. The earliest signs may be poor sucking ability, and the loss of head control and motor skills. These symptoms may be accompanied by loss of appetite, vomiting, irritability, continuous crying, and seizures. As the disorder progresses, symptoms may also include generalized weakness, lack of muscle tone, and episodes of lactic acidosis, which can lead to impairment of respiratory and kidney function.
1. Based on the information, what cell component do you think could be defective?
2. Briefly explain why you chose this particular organelle or cellular structure.