We examined the use of heparin-PF4 ELISA screening for heparin-induced thrombocytopenia (HIT) in critically ill persons. Using C-serotonin release assay (SRA) as the way of validating HIT, the authors found that in 31 patients tested negative by SRA, 22 also tested negative by heparin-PF4 ELISA.
(a.) Calculate the specificity of the heparingPF4 ELISA testing HIT.
(b.) Using a "literature derived sensitivity" of 95% and a prior probability of HIT occurence as 3.1%, find the positive predictive value.
(c.) Using the same information as part (b), find the negative predictive value.