The mutation rate to a lethal recessive genetic illness is


The mutation rate to a lethal, recessive genetic illness is 10-14. Individuals die before they get a chance to reproduce. Under mutation-selection balance, what is the equilibrium frequency of the heterozygous genotype? Imagine it was discovered that, in a population of Icelanders, the frequency of this allele was .01. Come up with a likely explanation for the high frequency of the allele.

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