Sotalol is a drug with beta-blocker and antiarrhythmic action. The kinetics of the metabolism of the drug were followed by concentration of the remaining non-metabolised sotalol at different times as tabulated in the table below.
Table: Concentration of non-metabolised sotalol as a function of time.
Time/ h : 0 : 10 : 20 : 30 : 40 : 50 : 60 :
[ sotalol] / nM: 2.00: 1.26: 0.80: 0.50: 0.32: 0.20: 0.13:
a) Determine the order of reaction using plot and discussion.
b) Calculate the rat of constant showing all working.
c) Calculate the half-life graphically and analytically (numerically ).