Rifaximin (Xifaxan)
An anon-absorbed oral antibiotic, was about as effective as ciprofloxacin for treatment of travelers' diarrhea, mostly caused by E. coli. It is not effective against infections associated with fever or blood in the stool or those caused by Campylobacter jejuni. Rifaximin has fewer adverse effects and drug interactions than systemic antibiotics, but should not be taken during pregnancy.