Ribonucleases and deoxyribonucleases
These enzymes are responsible for the degradation of dietary nucleic acids. Ribonucleases and deoxyribonucleases secreted by the pancreatic juice hydrolyze RNA and DNA to oligonucleotides. These are further hydrolyzed by pancreatic phosphodiesterases producing a mixture of 3' and 5' mononucleotides. Nucleotidases remove the phosphate groups hydrolytically releasing nucleosides.