Rf-values of acetaminophen and caffeine


Assignment:

A student obtained a silica gel TLC plat shown in figure by spotting samples of Midol, caffeine and acetaminophen on the plate, then eluting with petroleum ether: chloroform

  • What are the Rf-values of acetaminophen and caffeine, respectively?
  • Based on this TLC analysis, what are the ingredients in a tablet of Midol?
  • What are the mobile phase and the stationary phase in this TLC experiment?
  • No spots were observed visually when the TLC plate was removed from the developing chamber. How might the student effect visualization of the spots?
  • Another student accidentally used Midol PM in her experiment and observed only one spot. Speculate as to which spot was absent and offer a possible explanation for the difference in this student's result.
    1944_Midol.JPG

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Chemistry: Rf-values of acetaminophen and caffeine
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