Question 1
With regard to the asymmetric Heck reaction - from the rccent literature (2010-2014) please give three examples that use the intermolecular and three examples that employ the intramolecular asymmetric Heck reactions as key steps in total synthesis or as steps studied for asymmetric methodology development.
In your analysis of these publications outline the chiral ligands used and draw a catalytic cycle for one initermolecular and one intramolecular reaction.
Question 2:
With regard to the asymmetric palladium - catalysed allylic substitution reaction - from the recent literature (2010-2014) please give five examples that use this transformation as ahoy step in total synthesis. In your analysis of these publications outline the chiral ligands used and draw a catalytic cycle for one of the examples you have chosen.