Question- Tyrosine hydroxylase (TH) is an enzyme found in the nervous system. It hydroxylates tyrosine and initiates the synthesis of dopamine. It has been determined the Km of TH is smaller than the concentration of tyrosine in the CNS. This implies that
1) Tyrosine availability in CNS is a major regulator of dopamine synthesis
2) Dietary tyrosine has major impact on dopamine synthesis
3) Dopamine synthesis is not affected by fluctuations in tyrosine concentration
4) Dopamine level in the brain is directly correlated to tyrosine fluctuation in CNS
Please illustrate work if possible thanks