Question- Pravastatin is a cholesterol lowering drug whose mechanism of action is the inhibition of HMG-CoA reductase. If a patient takes a 40.0 mg dose of pravastatin what is the concentration of pravastatin in the blood? Assume the patient has 5.0 L of blood. The molecular weight of pravastatin is 425.
Pravastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 2.3 × 10-3 ?M. What fraction of the enzyme will have a bound substrate under the conditions described above? Assume the concentration of HMG-CoA is 15 ?M, and the KM for HMG-CoA reductase is 1.4 ?M.
After a period of time, all but 0.10% of the pravastatin in the blood is metabolized. What fraction of the enzyme will have bound substrate under these conditions?
Your answer must be supported by illustrations, Please answer with work shown to receive points