Problem:
During the 16-week primary observation period, the mean percentage change from baseline in the number of angioedema attacks per month was -91% in the 25-mg group, -97% in the 50-mg group, and -80% in the 75-mg group (Table 3 and Fig. S10). Among all 10 patients, the mean percentage change in the number of angioedema attacks per month between baseline and the latest assessment was -95% for all attacks and -93% for attacks that led to the use of on-demand therapy (Table 3 and Table S8). Because the screening period was shorter for some patients than for others, we performed a supportive analysis in which the baseline data included attacks that occurred during the 90-day historical attack period and attacks that occurred during the screening period, and the percentage change was similar to that when the baseline data included only attacks that occurred during the screening period (Table S9). Need Assignment Help?