Problem: Which priority nursing actions should the nurse take prior to administering penicillin to a client? Select all that apply. Inform the client that they will need be observed for 30 minutes after the injection. Inquire about a history of allergies to penicillin. Inform the client that they will need someone to drive them home. Have the client lie down and assess vital signs. Advise the client to rest for the remainder of the day. Need Assignment Help?