Discussion:
Polypeptide Chain Structure & Function
1. In the following polypeptide chain where do you expect to see bends, twists, and disulfide linkages forming?
2. Which ones of these amino acids is/are likely to be in the interior of a protein?
3. Mark the amino acids likely to contribute to the overall charge of the peptide in neutral pH.
Chain:
Ile-Ala-His-Thr-Tyr-Gly-Pro-Phe-Glu-Ala-Ala-Met-Cys-Lys-Trp-Glu-Ala-Gln-Pro-Asp-Gly-Met-Glu-Cys-Ala-Phe-His-Arg