Periimplant Sulcus Fluid Analysis (PISF)
This is not a parameter for clinical use but for experimental situations. However, it is important for us to know about it. Several biochemical mediators in the gingival crevicular fluid around natural teeth have been identified as potential host markers for periodontal disease activity and progression. A few studies have been reported on the association between the signs of periimplant inflammation and the levels of inflammatory mediators in the PISF. IL-1 Beta, PGE2, PDGF, enzymes from PMN, lactoferrin and elastase have been found in higher levels around affected implants than the control healthy ones.