Problem:
A 35-year-old patient newly diagnosed with a Methylenetetrahydrofolate reductase (MTHFR) gene mutation inquires about its potential impact on their overall health and nutrient utilization. The psychiatric nurse practitioner explains that this genetic variation can impair a critical enzymatic process involved in metabolism. Specifically, how does an MTHFR gene mutation primarily affect the body's metabolism and bioavailability of Vitamin B12, leading to a potential deficiency in this vitamin? A. It directly reduces the production of intrinsic factor, preventing Vitamin B12 absorption in the stomach. B. It causes increased urinary excretion of active Vitamin B12 through kidney dysfunction. C. It compromises the conversion of inactive folate to its active form, which is essential for the proper absorption and metabolic utilization of Vitamin B12. (Your Answer) D. It leads to the rapid enzymatic degradation of Vitamin B12 within the bloodstream before it can be used by cells. Need Assignment Help?