Problem: A new patient arrives at the office for treatment for depression. The patient reports taking simvastatin (Zocor) and lisinopril (Zestril). When selecting an antidepressant, the psychiatric-mental health nurse practitioner eliminates fluoxetine hydrochloride (Prozac), based on the knowledge that the combination can lead to increased plasma levels of the statin, resulting in an increased risk of muscle damage and rhabdomyolysis. What is the nurse practitioner's rationale? Need Assignment Help?
- Both medications are CYP450 3A4 inhibitors.
- Both medications are CYP450 3A4 substrates.
- One medication is a CYP450 3A4 substrate and one is a CYP450 3A4 inducer.
- One medication is a CYP450 3A4 substrate and one is a CYP450 3A4 inhibitor.