Outline some pharmacokinetic changes in geriatric population


Homework

Length: 3 to 4 pages.

Case Study: Polypharmacy

Mrs. A is a 71 year old widow with CHF and osteoarthritis who has recently been exhibiting quite unusual behavior. Her daughter is concerned about her mother's ability to remain independent and wishes to pursue nursing home admission arrangements. She fears the development of a dementing illness. Over the last two to three months Mrs. A has become confused, easily fatigued and very irritable. She has developed disturbing obsessive/compulsive behavior constantly complaining that her lace curtains were dirty and required frequent washing. Detailed questioning revealed that she thought they were yellow-green and possibly moldy. Her prescribed medications are:

a. Furosemide 40 mg daily in the morning
b. Digoxin 250 micrograms daily
c. Paracetamol 500 mg, 1-2 tablets 4-hourly PRN
d. Piroxicam 20 mg at night
e. Mylanta suspension, 20 ml PRN
f. Coloxyl 120 mg, 1-2 tablets at night

Task

a. Critically discuss this case study in terms of the problematic nature of this patient's pharmacological management.

b. Outline some pharmacokinetic changes in the geriatric population that may affect drug disposition.

c. Outline how changes in renal and hepatic function may affect treatment strategies.

d. In the drug regimen presented above - discuss potential side effects and potential interactions, if any?

e. Your response should include a discussion of the problems of polypharmacy as it is related to this case study and the assessment/management and educational strategies which could have been implemented to improve the outcome of Mrs. A.

Format your homework according to the give formatting requirements:

a. The answer must be double spaced, typed, using Times New Roman font (size 12), with one-inch margins on all sides.

b. The response also includes a cover page containing the title of the homework, the course title, the student's name, and the date. The cover page is not included in the required page length.

c. Also include a reference page. The references and Citations should follow APA format. The reference page is not included in the required page length.

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