Assignment Problem: Loss of expression of cadherin and integrin in epithelial tumours is a common event that enables cancer cells to metastasise (i.e. detach from the tumour and migrate to other parts of the body).
Q1. Explain how reduced cadherin expression in epithelial tumours would impact junctional complexes and enable metastasis.
Q2. Explain how reduced integrin expression in epithelial tumours would impact junctional complexes and enable metastasis.