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Lets say you have an mrna sequence then you have several

Lets say you have an mRNA sequence. Then you have several other mRNA sequences that are very similar to the original mRNA, but have a couple of mutations. Would the closest mRNA to the original be the one with the least mutations or that has mutations that aren't as severe (such as silent mutations compared to frameshift mutations)?

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Biology: Lets say you have an mrna sequence then you have several

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