Is there any direct incorporation of water in replication


Problem:

I have seen a paper in which deuterated water was used to follow dividing cells. The assumption was that deuterated water will be incorporated into newly synthesized DNA molecules.

Required:

Question: Is there any direct incorporation of water in the replication process?

Question: Is there any proton exchange?

Explain your reasoning.

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Biology: Is there any direct incorporation of water in replication
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