In the signal transduction lecture, we established that the BCR-ABL translocation creates a membrane bound receptor with constitutive kinase activity. What defect is associated with this oncogenic mutation?
A. An increase in phosphorylation of the substrate (compared to wild type)
B. A defect that attenuates signaling from the BCR-ABL kinase
C. A failure of the BCR-ABL fusion gene to localize to the plasma membrane
D. A decrease in phosphorylation of the substrate (compared to wild type)
E. Apoptosis