Imagine a receptor tyrosine kinase signaling pathway, which if upregulated too much leads to unwanted cell proliferation and tumorigenesis. Describe whether the therapeutic approaches described below would be effective. Explain your answer and focus it on the effect of the therapeutic on signal transduction.
a) An ATP analog drug that binds the ATP site in the receptor kinase domain. b) An ATP analog drug that binds the ATP site in a MAP kinase kinase. c) A GTP analog that binds Ras. d) A viral expression therapy that leads to increased levels of SOS in the cell