Illustrate the diabetic contract of the eye?
Diabetic Cataract:
1) Sorbitol Aldose Pathway: In patients with diabetes, there is increase in sugar alcohol which results in disturbance of NaK ATPase and concomitant lens swelling.
2) Auto-oxidation of protein
3) Theory of Non-enzymatic Glycosylation: According to this theory, the open chain of sugar attacks the amino acid of lens epithelium, resulting in S-S and thiol grouping and ultimately cataract formation.