Homework
Purpose
The purpose of this homework is for students to discuss how human genetic variations impact pharmacokinetics and pharmacodynamics of drugs and the application for use in the clinical setting.
Activity Learning Outcomes
Through this discussion, the student will demonstrate the ability to:
o Explain how pharmacogenomics is currently applied to clinical practice.
o Discuss the limitations of pharmacogenomics testing.
o Discuss ethical concerns related to pharmacogenomics testing and treatment.
Requirements:
In your post, respond to the following scenario (Hint: use the pharmgkb website to guide your responses):
• Before initiating abacavir, an anti-retroviral, for a newly diagnosed HIV positive patient the nurse practitioner orders HLA-B*5701 allele genetic testing. The test confirms that the patient carries the HLA-B*5701 allele.
o Describe what these results mean.
o Should the nurse practitioner prescribe abacavir in this case? If not, state why.
• A patient is prescribed antiplatelet therapy (clopidogrel) following an acute myocardial infarction (MI). Six months later, the patient suffers another acute MI. The patient has been adherent to therapy and the nurse practitioner suspects that clopidrogel may have been ineffective. How might genetic testing have been beneficial in this case?
• Identify 2 limitations of pharmacogenomics testing. Explain.
• Identify 2 ethical concerns of using pharmacogenomics testing. Explain.
Format your homework according to the following formatting requirements:
o The answer should be typed, using Times New Roman font (size 12), double spaced, with one-inch margins on all sides.
o The response also includes a cover page containing the title of the homework, the student's name, the course title, and the date. The cover page is not included in the required page length.
o Also include a reference page. The Citations and references must follow APA format. The reference page is not included in the required page length.