Problem:
A small amount of dominance can have a major effect in reducing the equilibrium frequency of a harmful allele. To confirm this for yourself, imagine an allele that is lethal when homozygous (s = 1) in a population. Suppose that the allele is maintained by mutation-selection balance with ? = 5 x 10-6.
Required:
Question: Calculate the equilibrium frequency of the allele in the case of complete recessive.
Show the pedigree and your calculation.