How might you isolate a mouse homologue of mnx


Problem:

The Drosophila Mnx protein is expressed in the proneural clusters. Experiments indicate that Mnx function is necessary for the activation of the Notch receptor by the Delta ligand.

Required:

Question 1:  What neuronal phenotype do you predict would arise from loss of function mutations in the Mnx gene? Explain your reasoning.

Question 2: How might you isolate a mouse homologue of Mnx?

Question 3: How would you determine if the mouse Mnx gene shares a similar role in mouse development?

Explain all the answers in detail.

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Biology: How might you isolate a mouse homologue of mnx
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