How many patients would be required to ensure 95 confidence


1. The following data were collected in a clinical trial to compare a new drug to a placebo for its effectiveness in lowering total serum cholesterol.

Generate a 95% confidence interval for the difference in mean total cholesterol levels between treatments.

New Drug

(n=75) Placebo

(n=75) Total Sample

(n=150)

Mean (SD) Total Serum Cholesterol 185.0 (24.5) 204.3 (21.8) 194.7 (23.2)

% Patients with Total Cholesterol < 200 78.0% 65.0% 71.5%

Upper CI. Lower CI. Based on confidence interval which of the following are true ?

How many patients would be required to ensure 95% confidence interval has a margin not exceeding 5%?

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