How man-made insulin analogues facilitate a tight glucose control in adults and children with diabetes mellitus? Hypoglycemia is the most commonly observed adverse reaction in patients using insulin: Availability of new short-acting (lispro, aspart and glulisine). Long acting analogs (glargine, detemir). Improved pharmacokinetic characteristics. Lesser variability and better reproducibility. Focus on the Pharmacokinetics of the different forms of insulin? Regular insulin, Humalog and Novolog. Lantus and Levimir. NPH please dont forget paraphrasing.