How is the genetic determination of sex established in humans?
In the diploid genome of human beings there are 46 chromosomes, 44 of them are autosomes and two are sex chromosomes. The individual inherits one of these chromosomes from every parent.
The human sex chromosomes are known as X chromosome and Y chromosome. Individuals having two X chromosomes (44 + XX) are female. Individuals having one X chromosome and one Y chromosome (44 + XY) are male. (Individuals 44 + YY do not exist as the chromosome Y is exclusively from paternal lineage.)