How does the inflammation mechanism work?
When some tissue injury happens histamine and other vasoactive substances (known as mediators of inflammation) are released, they cause vasodilation and the blood flow to the affected site enhances. Granulocyte leukocytes present in the blood are attracted to the site of the injury by substances called as chemotactic factors also released by the injured tissue and by the active granulocytes in the area. The granulocytes exit the capillaries by diapedesis, i.e., using pseudopods. Macrophages show in the region is activated too. These cells flood the extracellular space of the affected area trying to kill or eliminate harmful agents, to stop tissue necrosis and to isolate the damaged tissue.