How does polarity affect the diffusion of a substance if, Biology

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How does polarity affect the diffusion of a substance if

1. How does polarity affect the diffusion of a substance? If the substance is more polar, then it diffuses faster through the plasma membrane, correct?

2. Under what circumstances might it be useful to separate proteins in the absence of SDS-PAGE?

3. ABOUT Tay Sach's disease. Explain how are person can have a gene for the disease, but live a healthy life. Describe the symptoms and prognosis pf the disease.

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